Simple and efficient synthesis of 5‐substituted 1‐<i>H</i>‐tetrazoles using metal‐modified clay catalysts

Abstract

Abstract The synthesis of 5‐substituted 1‐ H ‐tetrazoles based on reaction of a series of aromatic nitriles with sodium azide was investigated. The reaction was catalyzed by modified montmorillonite K‐10 including Cu 2+ , Fe 3+ , Ni 2+ , and Zn 2+ metal ions. The best results obtained by Mont‐K10‐Cu catalyst. The catalysts were reused several times without loss of their activity. The present procedure offers advantages such as a shorter reaction time, simple workup, recovery, and reusability of the catalyst. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 22:168–173, 2011; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.20672