Publication | Closed Access
Biocatalysis in Organic Synthesis 7. Enantioselective Transesterification Catalyzed by an Acylase: Remarkable Influence of Remote Substitution and the Nature of the Solvent on the Selectivity1
23
Citations
0
References
1996
Year
Vinyl AcetateEnantioselective Transesterification CatalyzedEngineeringNatural SciencesBiocatalysisRemote SubstituentsOrganic Synthesis 7Organic ChemistryAspergillus SpeciesCatalysisHomogeneous CatalysisChemistryNatural Product SynthesisAsymmetric CatalysisRemote SubstitutionEnantioselective SynthesisBiomolecular Engineering
Acylase I from Aspergillus species catalyzes the reaction of transesterification between vinyl acetate and racemic derivatives of 2-(hydroxymethyl)piperidine. It has been found that the enantioselectivity of the reaction depends on the solvent. Also it has been observed that remote substituents have a great influence on the enantioselectivity.