Synthesis of some novel methylene‐bis‐pyrimidinyl‐spiro‐4‐thiazolidinones as biologically potent agents

Abstract

Abstract magnified image A series of novel methylene‐bis‐pyrimidinyl‐spiro‐4‐thiazolidinones 6a‐h have been synthesized by cyclocondensation of thioglycolic acid with methylene‐bis‐( N ‐cyclohexylidene‐ N ‐pyrimidine) 5a‐h , which in turn have been prepared by the reaction of cyclohexanone with methylene‐bis‐2‐aminopyrimidines 4a‐h , which are prepared by the reaction of guanidine hydrochloride with methylene‐bis‐chalcones 3a‐h . The compounds 3a‐h have been synthesized by the reaction of 5‐(3‐formyl‐4‐hydroxybenzyl)‐2‐hydroxybenzaldehyde 2 with various acetophenones in presence of KOH. The compound 2 is prepared by the reported method. The structures of the compounds synthesized have been confirmed by their elemental analysis and spectral data. Their antibacterial and antifungal activities have also been evaluated.