New one step synthesis of 3,5‐disubstituted 1,2,4‐oxadiazoles

Abstract

Abstract magnified image Disubstituted 1,2,4‐oxadiazoles have been synthesized in good yields and good purity in one pot procedure by reaction of aromatic nitriles, hydroxylamine hydrochloride and sodium carbonate in ethylene glycol under heating at 195°C. The structures of different 1,2,4‐oxadiazoles obtained were confirmed by 1 H, 13 C NMR and mass spectroscopy.