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One-Pot Ester Synthesis from Allyl and Benzyl Halides and Alcohols by Palladium-Catalyzed Carbonylation
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2011
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EngineeringOrganic ChemistryChemistryChemical EngineeringBenzyl HalidesOrganometallic CatalysisCatalysisPalladium-catalyzed CarbonylationNatural Product SynthesisAsymmetric CatalysisPharmacologyEnantioselective SynthesisBiomolecular EngineeringRelevant MoleculesAlkene MetathesisOne-pot Ester SynthesisTertiary AlcoholsSynthetic ChemistryBenzylic Halides
A mild and efficient one-pot synthesis of esters based on the Pd-catalyzed alkoxy- and aryloxycarbonylation of allylic and benzylic halides is described. The methodology has been applied to primary, secondary, and tertiary alcohols as well as to phenol derivatives. The O-protection of some biologically relevant molecules is also reported.