Concepedia

Publication | Closed Access

Facile Preparation of Aryl Sulfides Using Palladium Catalysis under Mild Conditions

23

Citations

0

References

2010

Year

Abstract

A convenient method for C-S cross-coupling of aryl bromides with various thiols has been developed that involves the use of a 1,1′-bis(diphenylphosphino)ferrocene (DPPF)-ligated palladium complex with N,N-diisopropylethylamine (DIPEA) as the base. This coupling is tolerant of a wide range of functional groups, including hydroxy, amino, cyano, nitro, formyl, and carboxyl groups.