Alkyl, Unsaturated, (Hetero)aryl, and N-Protected α-Amino Ketones by Acylation of Organometallic Reagents

Abstract

Stable and easily accessible N-acylbenzotriazoles, derived from a variety of aliphatic, unsaturated, (hetero)aromatic, and N-protected alpha-amino carboxylic acids, were reacted with Grignard and heteroaryllithium reagents to afford corresponding ketones in good to excellent yields.