Conjugate Addition of Organocuprates to Diethyl Vinylphosphonate - Concepedia

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Conjugate Addition of Organocuprates to Diethyl Vinylphosphonate

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References

1996

Year

I. Craig Baldwin, R. Paul Beckett, Jonathan M. J. Williams

EngineeringIntermediate α-MetalloalkylphosphonateConjugate Addition ProductOrganic ChemistryStereoselective SynthesisChemistryOrganocuprate ReagentsConjugate AdditionSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering

Abstract

The reaction of organocuprate reagents with diethyl vinylphosphonate affords the conjugate addition product. The intermediate α-metalloalkylphosphonate can be quenched with electrophiles to afford α-substituted alkylphosphonates.