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A Novel Approach to the Synthesis of Symmetric Optically Active 2,5-Dioxopiperazines
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1992
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Reduced PressureDiversity Oriented SynthesisHeterocyclicPhotochemistryActive 2,5-DioxopiperazinesNovel ApproachOrganic ChemistryStereoselective SynthesisChemistryHeterocycle ChemistryCyclic DipeptidesPharmacologySynthetic Chemistry
"Gas-solid-phase" method for the preparation of some cyclic dipeptides, 2,5-dioxopiperazines (diketopiperazines), is described. The method implies cyclodimerization of vaporous aliphatic α-amino acids in the presence of silica at reduced pressure and yields optically active 2,5-dioxopiperazines.