Publication | Closed Access
Diastereoselective Synthesis of 3-Hydroxyindanones via N-Heterocyclic Carbene Catalyzed [4+1] Annulation of Phthalaldehyde and 1,2-Diactivated Michael Acceptors
10
Citations
0
References
2011
Year
Asymmetric CatalysisChemical EngineeringCross-coupling ReactionEngineeringN-heterocyclic Carbene CatalyzedDiastereoselective SynthesisStetter ReactionProton ShiftOrganic ChemistryCatalysisStereoselective SynthesisChemistry1,2-Diactivated Michael AcceptorsHeterocycle ChemistryTandem ProcessSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
The diastereoselective synthesis of 2,2-disubstituted-3-hydroxy-indanones was realized by the N-heterocyclic carbene catalyzed [4+1] annulation of phthalaldehyde and 1,2-diactivated Michael acceptors, which involves a tandem process of Stetter reaction, proton shift, and aldol reaction.