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Asymmetric Reactions Catalyzed by Chiral Metal Complex. LXII. Efficient Asymmetric Hydrogenation of Imines Catalyzed by a Neutral Iridium(I) Complex of (4R,5R)-MOD-DIOP.
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1994
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Chemical EngineeringEngineeringNeutral IridiumAsymmetric Reactions CatalyzedChiral Metal ComplexOrganic ChemistryOrganometallic CatalysisCatalysisHomogeneous CatalysisChemistryHigh EnantioselectivityAsymmetric CatalysisEnantioselective SynthesisAsymmetric Hydrogenation
A neutral iridium(I) complex of (4R, 5R)-MOD-DIOP (1b) was found to be an efficient catalyst for the asymmetric hydrogenation of imines, N-(α-methylbenzylidene)benzylamine (4) and 2, 3, 3-trimethylindolenine (6), in the presence of tetrabutylammonium iodide. A high enantioselectivity with up to 81.4% ee was achieved.