Use of Bis-(chiral α-methylbenzyl)glycine Esters for Synthesis of Enantiopure β-Hydroxyamino Esters

Abstract

[reaction: see text] Aldol reactions using bis-(chiral alpha-methylbenzyl)glycine esters with aldehydes gave excellent diastereoselectivity. Thus, an enantiopure ribosylglycine was prepared for the synthesis of analogues of the natural antibiotics muraymycin. This method was extended for formation of beta-hydroxyamino esters.