A Highly Regio- and Stereoselective Carbocupration of Fluoroalkylated Internal Alkynes:  A Short Total Synthesis of the Antiestrogenic Drug Panomifene

Abstract

[reaction: see text] A highly regio- and stereoselective carbometalation reaction of fluoroalkylated internal alkynes with organocopper reagents is described. This reaction is utilized successfully in the short, stereoselective total synthesis of the antiestrogenic drug panomifene.