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Enantioselective Synthesis of Sulindac
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2001
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Key StepMedicinal ChemistryAnti-inflammatoryBioorganic ChemistryBiochemistryNatural SciencesMedicineOrganic ChemistryChemistryAsymmetric Kagan SulfoxidationPharmacologyAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisDrug DiscoveryNatural Product Synthesis
A highly enantioselective synthesis of Sulindac, a non-steroidal anti-inflammatory, is reported using the asymmetric Kagan sulfoxidation as key step.