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Enantioselective Synthesis of γ-Hydroxynorvaline
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1997
Year
DerivativesEngineeringPropylene OxideNatural SciencesDiversity-oriented SynthesisOrganic ChemistryNew SynthesisStereoselective SynthesisChemistryPharmacologyAsymmetric CatalysisPure γ-HydroxynorvalineSynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringNatural Product Synthesis
A new synthesis of enantiomerically pure γ-hydroxynorvaline is described. The key step involves diastereoselective alkylation of the chiral Schiff base 1 with primary iodo derivatives 2 easily prepared from propylene oxide.