Studies on Aryl H-Phosphonates; Part 2: A General Method for the Preparation of Alkyl H-Phosphonate Monoesters - Concepedia

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Studies on Aryl H-Phosphonates; Part 2: A General Method for the Preparation of Alkyl H-Phosphonate Monoesters

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1995

Year

Annika Kers, Inger Kers, Jacek Stawiński, Michał Sobkowski, Adam Kraszewski

Appropriate AlcoholPart 2Alkyl H-phosphonate MonoestersAvailable Diphenyl H-phosphonateOrganic ChemistryChemistrySynthesis MethodAryl H-phosphonatesSynthetic Chemistry

Abstract

A simple and efficient synthetic method for the preparation of alkyl H-phosphonate monoesters has been developed. The method consists of transesterification of commercially available diphenyl H-phosphonate with an appropriate alcohol under mild conditions, followed by ammonolysis of the in situ formed dialkyl and alkyl phenyl H-phosphonates.