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Efficient One-Pot Synthesis of Spirooxindole Derivatives by Ethylenediamine Diacetate Catalyzed Reactions in Water
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2009
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Chemical EngineeringNatural Product SynthesisBioorganic ChemistryEngineeringNovel OrganocatalystsNatural SciencesEthylenediamine DiacetateBenign CharacterOrganic ChemistryCatalysisChemistrySpirooxindole DerivativesSynthesis MethodPharmacologyInteresting Spirooxindole DerivativesSynthetic ChemistryEnantioselective SynthesisEfficient One-pot Synthesis
A simple and efficient one-pot synthetic approach was used for the preparation of biologically interesting spirooxindole derivatives by means of three-component reactions of isatins, malononitrile, and 1,3-dicarbonyl compounds catalyzed by ethylenediamine diacetate (EDDA) in an aqueous medium. This method is of great value because of its environmentally benign character, high yield, and easy handling.