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Synthesis of 1,2,4-Trioxepanes and 1,2,4-Trioxanes via H2O2-Mediated Reaction of Tertiary Carbinols
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2012
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Diversity Oriented SynthesisDerivativesH2o2-mediated ReactionTertiary CarbinolsBenzilic AcidAcidic ConditionsNatural SciencesDiversity-oriented SynthesisEngineeringOrganic ChemistryPhenyl SubstituentsChemistryPharmacologySynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
A facile and efficient method for the synthesis of 1,2,4-trioxepanes and 1,2,4-trioxanes from different carbinols having cyclopropyl and phenyl substituents has been developed. The corresponding hydroxyhydroperoxides were synthesized from 30% H<sub>2</sub>O<sub>2</sub> mediated reaction of carbinols in acidic conditions. This method provided access to novel 6,6-diaryl-substituted 1,2,4-trioxanes derived from benzilic acid.