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Three-Component Coupling of Isoquinoline, Activated Alkyne and Nitromethane: A Facile Synthesis of Nitromethyl Derivatives of 1,2-Dihydroisoquinolines
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2009
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Cross-coupling ReactionDerivativesEngineeringHeterocyclicThree-component CouplingNitromethyl DerivativesFacile SynthesisActivated AlkyneOrganic ChemistryCatalysisChemistryHigh SelectivityPharmacologyDerivative (Chemistry)Synthetic Chemistry
A three-component coupling (3CC) of isoquinoline, activated alkynes and nitromethane has been achieved for the first time to produce nitromethyl derivatives of dihydroisoquinoline in excellent yields with high selectivity. The reaction proceeds smoothly at 25 ˚C without catalyst.