Synthesis of (<i>R</i>)-4-Oxo-5-phosphononorvaline, an<i>N</i>-Methyl-D-aspartic Acid Receptor Selective β-Keto Phosphonate - Concepedia

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Synthesis of (<i>R</i>)-4-Oxo-5-phosphononorvaline, an<i>N</i>-Methyl-D-aspartic Acid Receptor Selective β-Keto Phosphonate

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References

1994

Year

Duane E. Rudisill, Jeffrey P. Whitten

Overall YieldBiochemistryMedicineMechanism Of ActionPharmacologyPharmaceutical ChemistrySynthetic ChemistryDrug Discovery-Aspartic Acid

Abstract

(R)-4-Oxo-5-phosphononorvaline (1), a selective NMDA glutamate site antagonist, has been synthesized in four steps (overall yield = 31%) from (R)-aspartic acid, without racemization.