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Synthesis of novel thiazolo[4,5-d]pyrimidine derivatives for antimicrobial, anti-HIV and anticancer investigation.
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1996
Year
Bioorganic ChemistryPrepared CompoundsAntimicrobial ChemotherapyChemistryHeterocycle ChemistryPharmaceutical ChemistryMedicinal ChemistryCyanoethoxy CarbonylAntimicrobial Drug DiscoveryAntimicrobial CompoundPharmacologyAntiviral CompoundBiomolecular EngineeringPromising Antifungal ActivityNatural SciencesAnticancer InvestigationMedicineDerivative (Chemistry)Drug Discovery
Some novel thiazolo[4,5-d]pyrimidines containing 6-arylideneamino (3a-e). 2-dicyanomethylidene (5a), 2-(cyanoethoxy carbonyl) methylidene (5b) or 2-hydrazono (7a, b) moieties were synthesized. The prepared compounds were tested in vitro for their antibacterial, antifungal, anti-HIV and anticancer activities. Most of them showed promising antifungal activity, but only a few compounds exhibited anticancer activity.