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A Practical One-Pot Synthesis of 5-Aryl-2-furaldehydes
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2001
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Cross-coupling ReactionEngineeringAlkene MetathesisPalladium-mediated Suzuki CouplingNatural SciencesDiversity-oriented SynthesisOrganic Chemistry-2-Furylboronic AcidCatalysisChemistrySynthesis MethodPractical One-pot SynthesisSynthetic ChemistryUseful One-pot Synthesis
A useful one-pot synthesis of 5-aryl-2-furaldehydes via palladium-mediated Suzuki coupling of aryl halides with in situ generated 5-(diethoxymethyl)-2-furylboronic acid is described. The procedure has general applicability, delivers high yields, and is amenable to scale-up.