Unique Reactivity of Aminoketones in the Trifluoromethylation with Trialkyl(trifluoromethyl)silanes

Abstract

Aminoketones were trifluoromethylated by using trialkyl(trifluoromethyl)silanes without any reaction promoters. Formation of cyclic intermediates is proposed to be possible transition states in this reaction. Moderate diastereoselectivities were observed in the trifluoromethylation of the aminoketones having a side chain.