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Anti-Candida activity of synthetic hydroxychalcones.
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1994
Year
Medicinal ChemistryAntifungal AgentBioorganic ChemistryAntifungal AgentsMedicineNatural SciencesDifferent Synthetic HydroxychalconesMedicinal FungiCandida SpeciesAntimicrobial CompoundSynthetic HydroxychalconesChalcone DerivativesPharmacologyBiomolecular EngineeringDrug DiscoveryDrug Resistance
The antifungal activity of different synthetic hydroxychalcones was determined against Candida species. It was revealed that the presence of hydroxyl groups at C-2, C-4, and C-2' in chalcone was essential to inhibit Candida growth. Among the chalcone derivatives examined, 2,4,2'-trihydroxy-5'-methylchalcone showed the most intensive anti-Candida activity, suggesting that it could be a potential therapeutic agent for candidosis.