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Iodine-Catalyzed C–N Cleavage of Tertiary Amines: Synthesis of Methylene-Bridged Bis-1,3-dicarbonyl Compounds
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2014
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Benign Catalytic SystemCross-coupling ReactionEngineeringNatural SciencesDiversity-oriented SynthesisMethylene-bridged Bis-1,3-dicarbonyl CompoundsIodine-catalyzed C–n CleavageOrganic ChemistryTertiary AminesCatalysisOrganometallic CatalysisChemistrySynthetic ChemistryBiomolecular Engineering
A novel and efficient iodine-catalyzed C–N cleavage of tertiary amines via an sp<sup>3</sup> C–H bond oxidative coupling reaction is described. A wide range of methylene-bridged bis-1,3-dicarbonyl compounds were synthesized in up to 92% yield by using an environmentally benign catalytic system in combination with 1,3-dicarbonyl compounds.