Effective and Versatile Functionalisation of Hexamethylbenzene Using N-F Reagents

Abstract

Effective direct introduction of alkoxy, amido, azido or halogeno functional groups on the benzylic position in hexamethylbenzene was mediated by the N-F reagents F-TEDA-BF4, NFTh, NFSi or FP-B800 in the presence of alcohols, carboxylic acids, cyanides or trimethylsilyl derivatives as sources of an external nucleophile.