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Synthesis of 3-Pyridylpropenoic Acid Esters via Heck Coupling of Substituted 3-Pyridyl Triflates
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1995
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Cross-coupling ReactionSubstituted 3-PyridylEngineeringSeveral 3-PyridinepropenoicOrganic ChemistryCatalysisAvailable 3-HydroxypyridinesChemistryHeck CouplingHeterocycle Chemistry3-Pyridylpropenoic Acid EstersSynthesis MethodSynthetic ChemistryBiomolecular Engineering
From commercially available 3-hydroxypyridines, several 3-pyridinepropenoic ethyl esters were prepared in good yield via Heck coupling of ethyl acrylate and the pyridyl triflate. In general, LiCl accelerated the coupling, but was not required for all reactions.