Preparation of Optically Active 8,8’-Disubstituted 1,1’-Biisoquinoline

Abstract

Synthesis of 1.1'-biisoquinolines having substituents in the 8.8'positions and their resolution by hplc on a chiral column on a preparative scale are described.Studies of stereoisomers which share an enantiomeric relationship constitute a large and fundamentally significant part of stereochemisay.Though the presence of a center of chirality is a necessary condition for the HETEROCYCLES, Vol.42.No. 1,1996 aromatic amines without racemization are now in progress.11.This is the first example of the resolution of chiral 1.1'-biisoquinoline nucleus.Recently, optical resolution of 1.1'-biisoquinoline-NY-dioxide was reported (M.Fujii and A. Honda,