Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification

Abstract

We have shown that metaGRS_2, that combined on the effects of more than 900 SNPs, provided best predictive ability for breast cancer in two different population-based cohorts. The strength of the effect of metaGRS₂ indicates that the GRS could potentially be used to develop more efficient strategies for breast cancer screening for genotyped women.