Substituted 2-(Cyanomethyl-amino)-acetamides by a Novel Three-Component Reaction

Abstract

A novel three-component, one-pot reaction between ­primary (S)-amino acid amides, aldehydes and isocyanides in the presence of acetic acid yielding substituted 2-(cyanomethyl-amino)-acetamides 4 in good yields, is described. First efforts to ­investigate the mechanism of this reaction were undertaken.