Concepedia

Ephedrine- and Pseudoephedrine-Derived Thioureas in Asymmetric Michael Additions of Keto Esters and Diketones to Nitroalkenes

Carsten Bolm, Angelika Marie Flock, Anke Krebs

Synlett · 2010 · 10 citations · 0 references

Concepts

Natural SciencesChemistryMedicinal ChemistryOrganic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsOrganic SynthesisPurine Chemistry

Abstract

Ephedrine-derived bifunctional thioureas have been synthesized and applied as organocatalysts in Michael additions of 1,3-dicarbonyl compounds to nitroalkenes.