Synthesis of Spirooxindolo/Spiroindano Nitro Pyrrolizidines through Regioselective Azomethine Ylide Cycloaddition Reaction

Abstract

Abstract Synthesis of a series of spirooxindolonitro pyrrolizidines and spiroindanonitro pyrrolizidines has been accomplished. The nonstabilized azomethine ylides generated from isatin and ninhydrin with proline reacted with nitro styrenes to regioselectively yield spirocycloadducts.