Concepedia

Solvent and Catalyst Free Three-component Coupling of Carbonyl Compounds, Amines and Triethylphosphite; a new Synthesis of α-Aminophosphonates

S. Chandrasekhar, Ch. Narsihmulu, S. Shameem Sultana, B. Saritha, S. Jaya Prakash

Synlett · 2003 · 37 citations · 0 references

Concepts

First SolventCarbonyl CompoundsCross-coupling ReactionEngineeringOrganic ChemistryNew SynthesisCatalysisChemistryAmbient TemperatureSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering

Abstract

The first solvent and catalyst free three-component coupling of carbonyl compounds, amines and triethylphosphite is achieved producing α-aminophosphonates at ambient temperature in very high yields.