Iron(III)-Catalyzed Synthesis of Dihydropyrimidinones. Improved Conditions for the Biginelli Reaction

Abstract

A general and practical route for the synthesis of dihydropyrimidinones 4 by a one-pot condensation of aldehydes, β-keto ester, and ureas is described using ferric chloride hexahydrate-mediated cyclocondensation reaction. Yields are significantly higher than utilizing classical Biginelli reaction conditions.