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The First Synthesis of (+)-Tanikolide, a Toxic and Antifungal Lactone from the Marine Cyanobacterium<i>Lyngbya majuscula</i>
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2000
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Key StepFirst SynthesisSpectroscopic DataBiosynthesisEngineeringAsymmetric CatalysisAntifungal AgentOrganic ChemistryMicrobiologyChemistryAntifungal LactoneCyanobacteriaNatural Product SynthesisAntimicrobial CompoundSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
(+)-Tanikolide, a toxic and antifungal lactone isolated from the marine cyanobacterium Lyngbya majuscula, has been synthesized enantioselectively by employing a catalytic asymmetric hydrogen transfer reaction as the key step. The synthesis has confirmed the validity of the proposed structure concluded on the basis of spectroscopic data.