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Synthesis of 3′-Deoxy-2′,3′-didehydro-3′-methylthymidine. A Potential Anti-HIV Agent
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1990
Year
Medicinal ChemistryPotential Anti-hiv AgentBioorganic ChemistryEngineeringBiochemistryVersatile MethodNatural SciencesAntiviral Drug DevelopmentOrganic ChemistrySynthetic ChemistryPharmacologyAntiviral CompoundDerivative (Chemistry)3′-Deoxy-2′,3′-didehydro NucleosidesBiomolecular Engineering
Starting from 1,2-O-isopropylidene-α-D-xylofuranose, a versatile method for the synthesis of branched 3′-deoxy-2′,3′-didehydro nucleosides is described and exemplified for an analogue of 3′-deoxy-2′,3′-didehydrothymidine (d4T).