Stereoselective Intramolecular Carbene C–H Insertion Catalyzed by Rhodium(III) Porphyrin Complexes - Concepedia

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Stereoselective Intramolecular Carbene C–H Insertion Catalyzed by Rhodium(III) Porphyrin Complexes

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2012

Year

Chi‐Ming Che, Vanessa Kar‐Yan Lo, Hung‐Yat Thu, Tsz‐Lung Lam, Wing‐Yiu Yu

Inorganic ChemistryChemical EngineeringCross-coupling ReactionPorphyrin ComplexesEngineeringCoordination ComplexOrganic ChemistryOrganometallic CatalysisCatalysisMolecular CatalysisChemistryBiomolecular Engineering

Abstract

Rhodium(III) porphyrin complexes [Rh(Por)Me] are catalytically active towards stereoselective intramolecular carbene C–H insertions of α-diazoacetamides to give <i>cis</i>-β-lactams or <i>trans</i>-γ-lactams in yields up to 99% with regioselectivities up to 100% and<i> cis</i>/<i>trans </i>ratios up to 83:17 for β-lactams.