Facile and selective copper–palladium catalyzed addition of terminal alkynes to activated alkynes in water

The Atom Economy—A Search for Synthetic Efficiency

BM Trost · Science · 1991 · 4.7K citations

Combinatorial Chemistry, Inorganic Chemistry, Chemical Engineering +14

Atom Economy—A Challenge for Organic Synthesis: Homogeneous Catalysis Leads the Way

Barry M. Trost · Angewandte Chemie International Edition in English · 1995 · 2.6K citations

Chemical Engineering, Cross-coupling Reaction, Engineering +12

.sigma.-Bond metathesis for carbon-hydrogen bonds of hydrocarbons and Sc-R (R = H, alkyl, aryl) bonds of permethylscandocene derivatives. Evidence for noninvolvement of the .pi. system in electrophilic activation of aromatic and vinylic C-H bonds

Mark E. Thompson, Steven M. Baxter, A. Ray Bulls et al. · Journal of the American Chemical Society · 1987 · 795 citations

Chemical Engineering, Engineering, Alkene Metathesis +13

A Highly Efficient Three-Component Coupling of Aldehyde, Alkyne, and Amines via C−H Activation Catalyzed by Gold in Water

Chunmei Wei, Chao‐Jun Li · Journal of the American Chemical Society · 2003 · 647 citations

Chemical Engineering, Mechanistic Rationale, Engineering +10

Facile Enantioselective Synthesis of Propargylic Alcohols by Direct Addition of Terminal Alkynes to Aldehydes

Doug E. Frantz, Roger Fässler, Erick M. Carreira · Journal of the American Chemical Society · 2000 · 594 citations

Asymmetric Catalysis, Natural Sciences, Diversity-oriented Synthesis +11