The Journal of Organic Chemistry · 2001 · 44 citations · 2 references
Chemical EngineeringCross-coupling ReactionEngineeringAlkene MetathesisAryl Ring SystemOrganic ChemistryMild Anionic MethodFacile PreparationsCatalysisO-quinone MethidesChemistryLow-temperature MethodHeterocycle ChemistryNatural Product SynthesisSynthetic ChemistryBiomolecular Engineering
A low-temperature method for generating o-quinone methides is described which permits facile introduction of assorted R substituents onto the aryl ring system at low temperature. The method is useful for the efficient preparation of ortho-ring-alkylated phenols.
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