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Thiourea-Catalyzed Direct Reductive Amination of Aldehydes
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2006
Year
Chemical EngineeringNovel OrganocatalystsEngineeringHantzsch EsterDiverse AminesOrganic ChemistryOrganometallic CatalysisCatalysisStereoselective SynthesisChemistryMetal-free ProcessAsymmetric CatalysisEnantioselective Synthesis
A hydrogen-bond-catalyzed direct reductive amination of aldehydes is reported. The acid- and metal-free process uses thiourea as organocatalyst and the Hantzsch ester for transfer-hydrogenation and allows for the high-yielding synthesis of diverse amines.