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Enantioselective Ring Opening of Epoxides with 4-Methoxyphenol Catalyzed by Gallium Heterobimetallic Complexes: An Efficient Method for the Synthesis of Optically Active 1,2-Diol Monoethers
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1998
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Asymmetric CatalysisChemical EngineeringEngineeringAlkene MetathesisEfficient MethodAchiral EpoxidesEnantioselective Ring OpeningHigh Catalytic ActivityOrganic ChemistryOrganometallic CatalysisCatalysisStereoselective SynthesisChemistryGallium Heterobimetallic ComplexesGallium ComplexesEnantioselective SynthesisBiomolecular Engineering
Useful chiral building blocks such as 1,2-diols can be obtained by the enantioselective ring opening of achiral epoxides with oxygen nucleophiles. The ring opening is carried out effectively (up to 94 % ee) with 4-methoxyphenol and catalytic amounts of gallium complexes. The novel complex GaSO 1 displays a particularly high catalytic activity.