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N-Acylation of 5-Substituted Indoles with Carboxylic Acids via DCC Coupling
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2004
Year
Cross-coupling ReactionEngineeringNatural SciencesDiversity-oriented SynthesisDcc CouplingElectron-withdrawing GroupOrganic ChemistrySynthetic ChemistryChemistryC-5 Electron-donating GroupBiomolecular Engineering5-Substituted Indoles
A method for the N-acylation of 5-substituted indoles with carboxylic acids using DCC and DMAP is presented. High yields were obtained when an electron-withdrawing group was present at C-5, however the method was less effective with a C-5 electron-donating group.