Synthesis · 2004 · 20 citations · 0 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistrySynthetic Medicinal ChemistryCarboxylic AcidsCarboxylic DerivativesCross-coupling ReactionsOrganic AcidsOrganic SynthesisAromatic Carboxylic AcidsCarboxylic Acid Derivative SynthesisCarboxylic Acid SynthesisElectron-donating GroupsElectron-withdrawing GroupsIndole ChemistryIndole DerivativesIndole Synthesis
A method for the N-acylation of 5-substituted indoles with carboxylic acids using DCC and DMAP is presented. High yields were obtained when an electron-withdrawing group was present at C-5, however the method was less effective with a C-5 electron-donating group.