Chemical and Pharmaceutical Bulletin · 1996 · 68 citations · 0 references
PharmacyBiochemistryMedicinal ChemistryDrug DiscoveryStructure-activity RelationshipsSynthetic Medicinal ChemistryMarine Bioactive CompoundsMarine Drug DiscoveryMarine Natural Product BiosynthesisMarine Natural ProductsMarine PharmacologyStructure-activity Relationship AnalysisBioactive Compounds From Marine SpongesBioactive Marine MetabolitesBioactive Marine Natural ProductsCircular DichroismCircular Dichroism AnalysisMarine Compound Structure ElucidationMarine Sponge MetabolitesStructure Elucidation Of Marine Natural Products
Altohyrtins A (1), B (2), and C (3) and 5-desacetylaltohyrtin A (4), extremely potent cytotoxic macrolides, have been isolated from the Okinawan marine sponge Hyrtios altum. The absolute stereostructures of these macrolides have been elucidated on the bases of detailed NMR analysis, application of the modified α-methoxy-α-(trifluoromethyl)phenylacetic acid (MTPA) method to the hexa-MTPA esters, and application of the circular dichroism (CD) exciton chirality method.