Observations on the Reaction of Dithioketals with<i>para</i>-lodotoluene Difluoride: A Novel Route to<i>gem</i>-Difluoro Compounds

Abstract

Reaction of dithioketals with 4-methyliodobenzene difluoride [4-(difluoroiodo)toluene] provides a simple, mild, and convenient method for conversion to the corresponding gem-difluoro compounds. The method is particularly suited to substrates which involve stabilised carbocationic intermediates.