Synthesis · 2013 · 85 citations · 0 references
Natural SciencesChemistryMedicinal ChemistryGreen ChemistryOrganic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisMacrocycle SynthesisMicrowave-assisted SynthesisOrganic SynthesisMicrowave-assisted CatalysisMicrowave-assisted Heterocycle SynthesisMicrowave-assisted Organic SynthesisPyrimidine Chemistry
An efficient strategy for the synthesis of various 1,4,5,6-tetrahydropyrimidine and 2-imidazoline derivatives has been reported. The reactions proceeded from nitriles with ethylenediamine or 1,3-diaminopropane via cascade cycloaddition in the presence of CuL<sub>2</sub> (L = 2-hydroxy-2-phenylacetate) to afford the corresponding 1,4,5,6-tetrahydropyrimidine or 2-imidazoline derivatives under reflux conditions or microwave irradiation in excellent yields.