Cascade Couplings of <i>N</i>-Alkyl-<i>N</i>-methacryloyl Benzamides with Ethers and Benzenesulfonohydrazides To Generate Isoquinoline-1,3(2<i>H</i>,4<i>H</i>)-dione Derivatives

Abstract

Two radical-mediated cascade couplings of N-alkyl-N-methacryloylbenzamides with different ethers and arylsulfonohydrazides to generate ether- and arylsulfonyl-substituted isoquinoline-1,3(2H,4H)-dione derivatives were developed. Both casccades proceeded via initially triggered functionalization of the alkene functions of the N-alkyl-N-methacryloylbenzamides, followed by ortho radical cyclizations onto the aromatic ring to give isoquinoline-1,3(2H,4H)-dione derivatives in good yields. These highly functionalized drug-like molecules will be valuable in drug discovery in the future.