TMC-86A, B and TMC-96, New Proteasome Inhibitors from Streptomyces sp. TC 1084 and Saccharothrix sp. TC 1094. II. Physico-chemical Properties and Structure Determination.

Abstract

TMC-86A, B and TMC-96, new proteasome inhibitors have been isolated from the fermentation broth of Streptomyces sp. TC 1084 and Saccharothrix sp. TC 1094, respectivelyl\ In the preceding paper, we have reported the taxonomy of producing strains, production, isolation, and biological activities of TMC-86A, B and TMC-961}. Here wedescribe the physico-chemical properties and structure determination of TMC-86A, B and TMC-96. The physico-chemical properties and NMRspectral data pp.63 -65