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Practical Large Scale Synthesis of tert-Butyl (3R,5S)-6-Hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate: Essential Building Block for HMG-CoA Reductase Inhibitors
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1995
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Medicinal ChemistryHmg-coa Reductase InhibitorsBiochemistryNatural SciencesMedicineTitle Compound 7Organic ChemistryStereoselective SynthesisChemistryMulti-kg ScalePharmacologyAsymmetric CatalysisPharmaceutical ChemistrySynthetic ChemistryEnantioselective SynthesisDrug DiscoveryEssential Building BlockNatural Product Synthesis
Title compound 7 (96% ee, > 98% de) is synthesized enantioselectively in six steps (36% overall yield) from the commercial β-keto ester 8 on a multi-kg scale.