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The Ru3(CO)12-Catalyzed Intermolecular [2 + 2 + 1] Cyclocoupling of Imines, Alkenes or Alkynes, and Carbon Monoxide: A New Synthesis of Functionalized γ-Lactams
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2000
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Ruthenium Carbonyl ResultsCross-coupling ReactionEngineeringCatalytic AmountBiochemistryHeterocyclicNatural SciencesFunctionalized γ-LactamsOrganic ChemistryNew SynthesisOrganometallic CatalysisCatalysisChemistryHeterocycle ChemistrySynthetic ChemistryBiomolecular EngineeringCarbon Monoxide
The reaction of imines which contain N-heterocycles or an ester group with alkenes or alkynes and carbon monoxide in the presence of a catalytic amount of a ruthenium carbonyl results in [2 + 2 + 1] cyclocoupling to give γ-butyrolactams in good yields.