Dehydrogenative Synthesis of C3-Azolylindoles via Copper-Promoted Annulative Direct Coupling of o-Alkynylanilines

Abstract

A copper-promoted annulative direct coupling of <i>o</i>-alkynylaniline derivatives with 1,3,4-oxadiazoles for the synthesis of C3-azolylindoles has been developed. The copper-based system provides a new protocol for the dehydrogenative construction of indole­–oxadiazole conjugations from nonhalogenated and nonmetalated starting materials.